Notre Dame has been impressive all season but in their game against USC when they faced a more dynamic offense, they struggled and allowed USC to put up 35 points on their defense. Indiana’s offense is explosive and they can catch the Irish off guard early in the game and build a good cushion and Notre Dame hasn’t played against a good quarterback like Rourke this season. Indiana’s defense is good enough where they can slow down the Irish too, making this game closer and more competitive with neither team building a huge lead. Indiana is 3-1 ATS on the road as an underdog of 3.5 to 10 points in the last two seasons and they are 5-0 ATS off a home win by 17 points or more. Notre Dame is 7-0 ATS after a bye week but they are 2-4 ATS at home after playing their last game on the road in the last two seasons.

Best bet: take the points with Indiana.