Creighton will beat Louisville and cover the game as they are 13-6-1 ATS in their last 18 games. Creighton has played their last five games coming into this match shooting 49.7% from the field and their 3 point shooting is better. Offensively they are more efficient right now than Louisville and their defense is a little better in their last five games. That should give them the edge over Louisville, who may have the crowd, but Creighton is 2-0 ATS in the first round of the NCAA tournament going back three seasons, and they are also 5-2 ATS in post season tournament games. Louisville doesn’t have the recent tournament experience that Creighton has so that gives them the edge as well.

Best bet: take the points with Creighton.