This one sets up perfectly for a Bills rout. The Niners are not having a great year. They are playing with a banged-up quarterback, missing their top defender in Bosa, and now they have to travel to Buffalo to play in cold and windy conditions. Yes, the Niners have Brock Purdy back and they were blasted last week without him, but that doesn't explain why they gave up 38 points in the contest. The defense has been hit hard by injuries and that will not help them here against a Buffalo team that has averaged 35 ppg at home. Buffalo has outscored their opponents by 16 ppg at home and that will win this one by at least 10 points.