We really like the underdog in this matchup. The line seems off when you consider that the Bills have lost some key pieces during the offseason, including two quality receivers in Stefon Diggs and Gabe Davis. They're coming into this game banged up, especially on defense. The Cardinals are coming into the season with an improved roster, and their offensive firepower is as strong as any team in the league.

This is a 4% play on the Cardinals on the spread.