(NFL) San Francisco vs. Arizona, 11/21/2022 8:15 PM, Score: 38 - 10
Point Spread: -8.00 | -110.00 San Francisco (Away)
Result: Win
This game will be played in Mexico city with the high altitude.

San Francisco has the superior offense and the opportunity to potentially Cards QB Colt McCoy as the Cardinals look to him to start on MNF in Mexico. SF is a big favorite but they should roll in this one, and should return to the USA with a big win under their belt behind Deebo Samuel, McCaffery, George Kittle and the tough SF 49ers defense.