The Cardinals lost their edge with a late October Thursday night home loss to the Packers. They have yet to regain it and I don't see that changing in this matchup. 

Arizona is 1-4 SU and ATS in its last five games. The Cardinals' defense has been below par the second half of the season. Their secondary has given up 14 TD passes with just one interception during the last five games. 

Matthew Stafford and Cooper Kupp, who had a superstar season, can take advantage. Stafford threw for a career-high 41 TD passes in his first year with Rams offensive guru coach Sean McVay while Kupp led the NFL in receptions, receiving yards and receiving TD's, emerging as the top wide receiver in the NFL. Stafford had no problem in two games against the Cardinals this season, completing 69 percent for 567 yards and a 5-to-1 touchdown-to-interception ratio. 

The Rams are going to get their points here. I don't see the Cardinals keeping up. I give a huge plus to Aaron Donald and a Rams defense line that is peaking against an Arizona offensive line that has sprung leaks and doesn't have a quality healthy running back left. 

This puts tremendous pressure on Kyler Murray, who hasn't been the same dominant force he was earlier in the season before missing four games. Minus superstar wide receiver and security blanket DeAndre Hopkins, the Cardinals are far less dangerous through the air and in the red zone. Arizona's offense mainly consists of a bunch of 5-yard passes for Murray, which isn't going to get the job done. 

McVay is 5-1 against Cardinals coach Kliff Kingsbury. During these six meetings the Rams have held Murray in check. Murray's averaged 233.2 passing yards, 6.8 yards per attempt with eight all-purpose TD's and nine turnovers along with being sacked 18 times.