Afternoon Annihilation - Scott "The Bulldog" Rickenbach NFL Rotation #459 Saturday 8* San Francisco 49ers (+) @ Arizona Cardinals @ 4:30 ET - Keep in mind, the 49ers have already been playing their "home" games at this venue in Arizona due to covid-related restrictions imposed in California. That said, this isn't much of a "road" game for the Niners and I love the fact that they are a sizable dog here despite the fact they deserved much better than what they got at Dallas last week. That loss to the Cowboys was despite a huge yardage edge of 167 yards and is helping to give us line value this week. Keep in mind, the Cardinals are off a key win over the Eagles last week and could fall flat here. The 49ers will be up for facing a divisional foe and with the ability to play the role of spoiler and note that Arizona is just 2-6 ATS the last 8 times they have been a home favorite. The Niners have covered 7 of their last 10 road games. Look for those trends to continue here. 8* SAN FRANCISCO