The 49ers have been the dominant team in the NFC for a significant part of the season. However, I have reservations about their ability to defeat Detroit by a margin greater than a touchdown. Deebo Samuel's shoulder condition could significantly influence the 49ers' offensive performance. Additionally, the Lions ranked third in the NFL for yards allowed per game on the road, and Brock Purdy showed moments of inconsistency against Green Bay. I'll take the Lions in this scenario.