Although Georgetown has the better win-loss record, Creighton is much better battle-tested. The Bluejays have faced the 61st strongest schedule according to KenPom, and Georgetown's strength of schedule is only 348th.
The Hoyas' inconsistency, especially on the defensive end, makes them a poor matchup against Creighton's high-tempo, efficient offense. Creighton's depth and the ability to spread the floor will likely overwhelm Georgetown's defense, which has struggled against more disciplined and talented teams, as seen in the Hoyas' 84-63 loss to Notre Dame and 73-60 loss to West Virginia. Expect the Bluejays to win convincingly and also cover the spread.

2% on Creighton