Arizona at St. Louis 8:25 ET
Cardinals (+) over Rams- These two clubs rely on defense to set up their offenses and St. Louis is coming off two consecutive shutouts over the Raiders (52-0) and Redskins (24-0). Arizona is allowing 18.3 points per contest while the Rams allow 21.9 points per game. The Cardinals are the 'injured' party here as they have now lost their running back Andre Ellington for the season as well as they already sidelined quarterback Carson Palmer and Larry Fitzgerald is questionable. The Rams are 4-0 ATS in their last four games while Arizona is 8-1 ATS on the road against teams with a losing home record and they are 10-4 ATS in the last 14 meetings. Take ARIZONA!