Arizona at San Francisco 4:05 ET
49ers (+) over Cardinals- Arizona who has the NFL's highest scoring offense already crushed the Niners in September 47-4 and I don't think they are afraid of anything San Francisco can throw at them. Although, with Colin Kaepernick sidelined San Francisco will have a better chance of getting the ball down field with Blaine Gabbert as starting quarterback. Kaepernick threw two pick-six touchdowns within the first six minutes in week three and at home this time the 49ers look for better results where they are 3-2 on the season. Take SAN FRANCISCO!