San Francisco at San Diego 6:40 ET
Padres over Giants- A little strange history between these two last season as the Giants won the first nine meetings and San Diego responded by winning eight of the final 10 meetings. San Francisco will start veteran Matt Cain (4-8, 5.65 ERA) who claims to be fully healthy for the first time in four years seasons but had a 7.82 ERA in spring training. The Padres will start Luis Perdomo (9-10, 5.71) who earned a win over the Giants last season was 0-1 in the spring with a 2.41 ERA. Take the PADRES!