San Diego at San Francisco 4:10 ET
Padres over Giants- The Giants have lost four straight and five of seven to open the season, including a three-game sweep in Los Angeles against the Dodgers to start the week. The San Francisco Giants will get the opportunity to introduce manager Bob Melvin to their fans when they host their home opener against the San Diego Padres on Friday afternoon. The clubs met to open the Giants' season in San Diego, where Melvin was the manager the past two years. He recorded his first two Giants wins in the middle two games of the series, before and after the Padres earned a split by winning on Thursday and Sunday. Padres right-hander Dylan Cease (0-1, 3.86 ERA), who will get the call in the rematch. Acquired in a trade from the Chicago White Sox in March, Cease took the loss in his Padres debut despite allowing three earned runs (two earned) and two hits in 4 2/3 innings. He walked two and struck out six. Cease had beaten the Giants in both previous meetings. Over three career appearances, he's gone 2-1 with a 2.45 ERA. One of the wins came in his only previous visit to San Francisco, a 7-3 White Sox win in which he allowed just one run in five innings. For the second straight start, he will be matched up with right-hander Jordan Hicks (1-0, 0.00), who shut out the Padres on three hits over five innings to earn a win in his Giants debut. Take SAN DIEGO!