Xavier is in safe position to make the NCAA tournament this season and it's all going to be about seeding for the Musketeers going forward. DePaul has been working their way through another disappointing Big East campaign and they are not very competitive in this conference again. This is a big number for Xavier to be laying without Edmond Sumner, but I like other Musketeers to step up and help cover. DePaul is 3-12-1 ATS in its last 16 road games, and Xavier whipped the Blue Demons twice by a combined 41 points last season. Lay the points with a Xavier team that's hitting its stride. This should be a game where Xavier cruises on their home court to a 20+ pt win.