The Fighting Irish are a solid offensive team, and Louisville does not have the firepower to keep pace on Saturday. The Cardinals tend to struggle in their trips to South Bend, covering the spread just 2x in their last 9 games. Notre Dame is 9-2 in its last 11 Saturday home games, and Louisville is winless on the road. The Cardinals have only covered the spread 6 times in their last 20 games, so expect a blowout win here from Notre Dame.