Nick Bosa is back and healthy and will be facing an inexperienced left tackle, Alaric Jackson, for much of the game, testing the second-year undrafted free agent. This will be Jackson’s first career start at left tackle. They have had enough trouble protecting Stafford this season, and now this? The 49ers also get back several other pieces on defense this week. Yes, there will be no Deebo, but Brandon Ayuk, George Kittle, and the newly acquired McCaffrey can make up for Deebos absence. The 49ers have owned the Rams in the regular season, and they win this one, also. 49ers -1.