Missouri vs Kansas Picks, Prediction, Odds, and Line Movement for Friday September 11 2026
Missouri and Kansas both enter Saturday's matchup fresh off lopsided wins over overmatched FCS opponents, and bettors weighing this week's college football picks will want to look past those blowout scores to figure out how much ground Kansas has actually closed. For more angles across the slate, check out our college football predictions before kickoff. Missouri is currently favored at -5.5, with Kansas getting the points at +5.5, while the total sits at 50.5.
TLDR: Quick Picks and Prediction
- Spread Pick: Missouri -5.5
- Total Pick: Over 50.5
- Projected Final Score: Missouri 31, Kansas 21
Odds and Line Movement
Current Odds
| Market | Missouri | Kansas | Total |
|---|---|---|---|
| Spread | -5.5 (-108) | +5.5 (-112) | - |
| Total | - | - | Over 50.5 (-115) / Under 50.5 (-105) |
Line Movement - Spread
| Date | Missouri | Kansas |
|---|---|---|
| 09/07 | -5.5 (-108) | +5.5 (-112) |
| 09/07 | -6 (-110) | +6 (-110) |
| 09/07 | -6 (-112) | +6 (-108) |
| 09/07 | -6.5 (-110) | +6.5 (-110) |
| 09/07 | -6.5 (-112) | +6.5 (-108) |
| 09/07 | -6.5 (-108) | +6.5 (-112) |
| 09/07 | -6 (-115) | +6 (-105) |
| 09/06 | -6 (-110) | +6 (-110) |
| 09/06 | -6 (-115) | +6 (-105) |
| 09/06 | -6.5 (-110) | +6.5 (-110) |
Line Movement - Total
| Date | Over | Under |
|---|---|---|
| 09/09 | 50.5 (-115) | 50.5 (-105) |
| 09/08 | 50.5 (-108) | 50.5 (-112) |
| 09/08 | 50.5 (-115) | 50.5 (-105) |
| 09/08 | 50.5 (-108) | 50.5 (-112) |
| 09/08 | 50.5 (-115) | 50.5 (-105) |
| 09/06 | 50.5 (-110) | 50.5 (-110) |
| 09/06 | 50.5 (-115) | 50.5 (-105) |
| 09/06 | 51.5 (-115) | 51.5 (-105) |
Missouri vs Kansas Key Matchups and Game Preview
Missouri Season Opener
Missouri kicked things off with a 54-14 home win over FCS-level Arkansas-Pine Bluff. The Golden Lions went 4-8 last season with a 60-point loss to Texas Tech, so the outcome of that one was never in any real doubt. Missouri out-gained Pine Bluff 562-198 and the Tigers held a 33-13 edge in first downs.
MIZZ Quarterback Debut
Transfer QB Austin Simmons went 17-of-19 for 252 yards with four touchdowns in his debut, giving Missouri an efficient and explosive start to the season through the air.
Kansas Season Opener
Kansas opened its campaign with a 51-6 home win over Long Island. The Jayhawks out-gained the Sharks 613-146 and held a 29-11 advantage in first downs, another dominant showing against an overmatched opponent.
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KU Quarterback Debut
Making his first career start, sophomore QB Isaiah Marshall went 14-of-19 through the air for 246 yards and two touchdowns while also adding 49 yards on the ground, giving Kansas a dual-threat dimension at the position.
Missouri Series History
Missouri earned a 42-31 home win over the Jayhawks last season, which was the first time these squads have met since they were conference foes in 2011. The Tigers out-gained the Jayhawks 595-254 in last year's contest with a 28-13 edge in first downs.
Tigers Path Forward
Missouri will likely face an uphill road in the SEC this season, but in this specific matchup against the Jayhawks, this game is lined over a touchdown. Missouri left very little doubt over who the superior team was last year, and there isn't much evidence yet that Kansas has closed that gap.
Betting Trends: MIZZ vs KU
Both programs demolished their Week 1 opponents, with Missouri out-gaining Arkansas-Pine Bluff 562-198 and Kansas out-gaining Long Island 613-146. Last season's meeting saw Missouri control the game from start to finish, out-gaining Kansas 595-254 with a 28-13 first-down advantage en route to a 42-31 win. Kansas figures to be improved from last year, and Missouri has taken a step back, but the gap between these two programs still appears meaningful.
Key Injuries and Things To Know: MIZZ vs KU
No specific injury designations were included in the available matchup information for either Missouri or Kansas. The bigger storyline entering this game is how each new starting quarterback performed in their debut, with Austin Simmons going 17-of-19 for Missouri and Isaiah Marshall going 14-of-19 with a rushing touchdown threat for Kansas.
Missouri vs Kansas Side and Over/Under Picks
- Spread Pick: Missouri -5.5
- Total Pick: Over 50.5
Missouri left very little doubt over who the superior team was last year, and there isn't enough evidence yet that Kansas has closed that gap. With both quarterbacks flashing efficiency and explosiveness in their debuts, the over also has appeal at 50.5.
Final Score Prediction
- Missouri: 31
- Kansas: 21
How to Wager On Missouri vs Kansas
Bettors looking to expand their approach to this Missouri vs Kansas matchup have a few additional resources worth exploring. Our AI picks break down data-driven angles for the game, while our Dimers review and Oddible review both provide additional model-based perspectives that can be used alongside the Missouri spread and over 50.5 total outlined above.
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