College Basketball Parlay Picks for Wednesday, December 17, 2025

By: Kim Smith Published 12/17/2025, 03:30 AM ET

College basketball continues to deliver strong betting opportunities as conference play ramps up, and Wednesday’s slate features a pair of matchups that set up well from a betting perspective. By focusing on home-court advantages, recent form, and clear talent gaps, this two-leg parlay targets teams in favorable positions to control the game flow and cover the number.

Check out our parlays, as well as all of our college basketball picks.

College Basketball Parlay

  • Creighton vs Xavier – Xavier -2.5 (-115)
  • Alabama State vs Cincinnati – Cincinnati -21.5 (-112)

Leg 1 – Creighton Bluejays vs Xavier Musketeers

This Big East opener sets up well for Xavier, especially at the Cintas Center, where the Musketeers have been dominant. Xavier enters on a five-game winning streak, while Creighton is riding a three-game road skid, including a 21-point loss at Nebraska.

Xavier has been the more consistent team on both ends of the floor, averaging 78.4 PPG while allowing just 71.5 PPG, and they force turnovers at a higher rate than Creighton. The Musketeers also have the edge in ball movement (18.9 assists per game) and defensive activity (7.4 steals per game).

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Creighton’s offense has struggled away from home, and their shooting efficiency dips noticeably on the road. In a tight Big East matchup, the team with better form, home-court advantage, and defensive pressure usually wins — and that’s Xavier in this spot. Check out the full Xavier vs Creighton prediction.

Pick: Xavier -2.5

Leg 2 – Alabama State Hornets vs Cincinnati Bearcats

This is a clear mismatch. Cincinnati owns a 95.6% win probability per ESPN Analytics and is 6–1 at home, while Alabama State is 1–6 on the road and has dropped four straight games.

The Bearcats allow just 67.0 points per game, and Alabama State has struggled to score efficiently against higher-level competition. Cincinnati’s size advantage on the glass (39.6 RPG) and interior defense should limit second-chance opportunities and force Alabama State into low-percentage shots.

Even though Cincinnati has been inconsistent recently, this is a get-right spot against an overmatched opponent. With depth, physicality, and home-court advantage, the Bearcats are in position to build a sizable lead and extend it in the second half. Check out the full Cincinnati vs Alabama State prediction.

Pick: Cincinnati -21.5

Final Thoughts

This parlay combines home-court edges and current form with clear talent gaps:

A broad list of handicappers publishing premium picks across NFL, NBA, CBB, NHL, CFL, and soccer, including Rob Vincilleti, Ben Burns, Mike Lundin, Sean Higgs, Ross Benjamin, and algorithmic teams like Advanced Sports AI.

Ben Burns Billy Coleman Bruce Marshall Bryan Power Chip Chirimbes David Delano David Hess Jackie Mack Jesse Schule Joe Duffy Joseph D'Amico Marc David Mark Ruelle Mark Zinno Mike Fink Mike Lundin Nick Parsons Pro Sports Picks Razor Ray Monohan Ricky Tran Rob Vinciletti Rocky Atkinson Ross Benjamin Sean Higgs Sniper Wes Stephen Nover Steve Seagrave Terry Edelmann The Gold Sheet Tom Macrina Tony Karpinski Trent Bets Will Rogers
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