Duke vs Louisville Picks and Predictions for Tuesday, January 6, 2026
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Duke vs Louisville Information
The Duke Blue Devils will continue their road trip on Tuesday night, facing the Louisville Cardinals in Louisville, KY, at 7:00 PM. Duke is currently ranked #6 in the nation, boasting an overall record of 13 wins and one loss. The team has won 4 of its last 5 games, including 2 consecutive victories, with its most recent win a 4-point road triumph against Florida State. The Louisville Cardinals return home ranked #20 nationally, with a record of 11 wins and three losses. They have lost 2 of their last 5 games, including a recent 4-point road loss to Stanford that ended their 2-game winning streak. For more college basketball news, check out our College Basketball Picks.
Duke Preview
The Duke offense has carried the team this season, averaging 87.3 points on 50% shooting from the floor after the Blue Devils scored 91 points in their win against Florida State. Defensively, Duke has held their own, allowing 65.5 points per game this season, but gave up 87 points to Florida State last time out, despite the win. Cameron Boozer leads the Duke offense this season, averaging 23 points, 9.8 rebounds, and 4.2 assists. Isaiah Evans is second on the team, averaging 13.4 points, while Patrick Ngongba II averages 11 points per game. Caleb Foster is 4th on the team, averaging 9.5 points in just under 26 minutes per game.
Louisville Preview
Offensively, Louisville has scored the ball well this season, averaging 90.4 points on 47% from the field, but it scored only 76 points in its loss to Stanford. Defensively, Lou was allowing 69.1 points per game this season, but gave up eighty points last time. Ryan Conwell leads the Louisville offense this season, averaging 19.6 points per game. Mikel Brown Jr. averages 16.6 points, and Isaac McNeely averages 11.6 points per game. Sananda Fru is averaging 11.1 points to go along with a team-leading 6.9 rebounds per game.
Duke vs Louisville Prediction
Duke is the better team in this matchup, and it will show Tuesday night. The Blue Devils are the deeper, healthier team in this game. Look for Duke to overwhelm a short-handed Louisville team start to finish Tuesday night. The Blue Devils have the better offense and the size and depth to get the job done. Take Duke to pull off a narrow ACC victory Tuesday night to remain undefeated in conference play. Final Score Prediction, Duke Blue Devils win and cover 81-74.
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Best Picks:
- Duke Blue Devils -1.5
- Under 162.5
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