Iowa State vs Creighton Picks and Prediction for Tuesday, November 25, 2025

By: Jake Allman Published 11/25/2025, 12:05 AM ET

Iowa State arrives in Las Vegas with a 4-0 start thanks to excellent pace, pressure, and scoring that hasn’t slowed. The Cyclones average 95.5 points on 54 percent shooting while forcing 12.8 steals per game, creating quick transition points. Creighton sits at 3-1 and plays a more structured style, but this matchup puts the Bluejays in front of one of the most efficient early-season offenses in the country. Iowa State is listed as a 9.5-point favorite with a total of 150.5, and both numbers reflect how decisive the first four games have been for the Cyclones. Big board, bigger value — see our winning college basketball predictions.

Iowa State Preview

Iowa State relies heavily on Tamin Lipsey, whose 19.0 points, 5.3 assists, and 3.8 steals per game set the tone on both ends. His shooting at 57.7 percent from the field and ability to create transition chances push the Cyclones’ tempo. Joshua Jefferson adds an interior scoring presence with 18.8 points and 7.8 rebounds on 67.5 percent shooting. Milan Momcilovic stretches defenses at 15.3 points and 43.3 percent from deep, while Blake Buchanan grabs rebounds, provides rim protection, and timely scoring. The Cyclones also hit 35.6 percent from three and have multiple guards capable of handling pressure, which keeps the turnovers low and strengthens each offensive possession. The four wins have all come by at least 16 points, and the matchup predictor is giving them a 78.6 percent chance of winning. The best sportsbooks are the best way to go when you are betting on Iowa State.

Creighton Preview

Creighton has a balanced roster from top to bottom, led by Blake Harper’s 13.0 points and 7.5 rebounds on 56.3 percent shooting. Owen Freeman has been highly efficient at 10.8 points and 74.1 percent from the field, and Nik Graves chips in 10.8 points with 3.5 assists. Rebounding is a strength at 42.5 boards per game, but Creighton’s perimeter shooting sits at just 27 percent so far. That’s a tough fit against a Cyclones team that thrives on turning missed shots and forced turnovers into instant transition. Several Bluejays players average more than one turnover per game, and matching up against Iowa State’s pressure defense must worry the Creighton staff. Creighton’s scoring is steady, but without a high-volume scorer, climbing back from double-digit runs will be difficult. Make sure you know about how the fans are looking on prediction markets for Creighton with the Onyx Odds promo code.

Iowa State vs Creighton Pick

Iowa State’s combination of pace, pressure, and shooting gives the Cyclones an advantage to control this matchup. Creighton’s rebounding helps keep them competitive, but the turnover differential and scoring tilt this heavily toward Iowa State. Lipsey’s playmaking, paired with Jefferson’s shooting should allow the Cyclones to create separation early and maintain it. Iowa State 86, Creighton 70. Getting the most out of your bets on Iowa State vs Creighton can be done by using the Fanatics Sportsbook promo code.

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