Loyola Chicago Ramblers vs San Francisco Dons Picks & Predictions — Wednesday, December 17, 2025

By: Kim Smith Published 12/17/2025, 02:10 AM ET

Loyola Chicago heads west to take on San Francisco in a late-night matchup at the Chase Center. While both teams have had uneven starts to the season, the analytics and betting markets heavily favor the Dons, especially with the Ramblers struggling away from home. The Dons vs Ramblers will be a great matchup potentially, but you can find all of our free college basketball picks and find the game you are looking for.

Loyola Chicago Ramblers Breakdown

Loyola Chicago enters at 3–8 overall, averaging just 68.3 points per game, which has been a major issue throughout the season. The Ramblers shoot only 41% from the field and rank near the bottom offensively among mid-major programs.

Miles Rubin leads the team at 12.2 PPG while shooting an impressive 64.3%, but free-throw shooting (59.1%) and a lack of perimeter consistency have limited Loyola’s scoring ceiling. Defensively, they allow 75.9 PPG, and the team struggles to generate steals (3.6 per game), making it difficult to force turnovers or create easy points.

On the road, Loyola has been especially vulnerable, and their recent loss to Chicago State highlighted ongoing defensive lapses.

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San Francisco Dons Breakdown

San Francisco comes in at 6–5 overall and has been much more reliable at home with a 4–1 record. The Dons play at a controlled pace, averaging 74.6 PPG while allowing just 69.5 PPG, giving them a clear defensive edge in this matchup.

Ryan Beasley leads the team with 13.8 PPG, and while San Francisco doesn’t overwhelm opponents offensively, they defend well, rebound effectively (37.6 RPG), and protect the rim (4.1 blocks per game). Their efficiency and discipline tend to wear down teams that struggle to score consistently—exactly the profile Loyola Chicago fits right now.

Despite coming off a loss, San Francisco’s home court and defensive structure remain strong advantages.

Key Matchups to Watch

Offensive efficiency: Loyola’s scoring struggles vs. San Francisco’s solid half-court defense
Rebounding margin: San Francisco’s edge on the glass could limit Loyola’s second chances
Home-court impact: The Dons have been significantly better in San Francisco

Prediction & Best Bets

Given Loyola Chicago’s offensive limitations and San Francisco’s defensive consistency at home, this game sets up well for the Dons to control the tempo and pull away in the second half. Make sure you know about how the fans are looking on prediction markets for San Francisco with the Fliff promo code. The best sportsbooks are the best way to go when you are betting on Loyola Chicago. Make sure when you place your Loyola Chicago vs San Francisco bet you are using the bet365 bonus code.

Best Pick: San Francisco Dons -12.5

Lean: Under 142.5 total points

Final Score Prediction: San Francisco 76, Loyola Chicago 60

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