Memphis vs Louisville Picks and Predictions for Saturday December 13, 2025
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Memphis heads to the KFC Yum! Center to face No. 11 Louisville on Saturday afternoon in a non-conference matchup that looks lopsided on paper. Tip-off is set for 3:30 PM Eastern Time on ESPN, with Louisville listed as a heavy favorite according to ESPN Analytics, which gives the Cardinals a 93.6 percent win probability. Memphis enters at 4-4 overall and 0-1 on the road, while Louisville sits at 8-1 and a perfect 6-0 at home. Big board, bigger value — see our winning college basketball predictions.
Memphis Preview
The Tigers have quietly put together a three-game winning streak, beating Baylor, New Orleans, and Southern Illinois. Those wins came by controlling pace and forcing mistakes, as Memphis averages 8.3 steals per game and holds opponents to 74.1 points. Dug McDaniel drives the offense with 13.9 points and 6.4 assists per game, but shooting has been an issue with the guard shooting just 38 percent from the field. Memphis averages 76.0 points per game on 43 percent shooting, numbers that are solid but not intimidating against more-talented competition.
Rebounding and depth off the bench remain concerns for the Tigers when stepping up in class. Memphis pulls down 37.5 rebounds per game, well below what Louisville brings to the table. Turnovers also show up at times during key stretches, with the Tigers committing over 13 per game, which can snowball quickly in on the road. The recent wins are encouraging, but two losses to Wake Forest and Purdue highlight the gap when Memphis faces highly talented opponents.
Louisville Preview
Louisville has been dominant at home and efficient across the board. The Cardinals average 93.8 points per game while allowing just 67.6, one of the strongest scoring margins in the country so far. Ryan Conwell leads the way with 19.7 points per game and shoots 42 percent from three, giving Louisville a reliable perimeter threat. Sananda Fru adds strength inside with averages of 10.6 points, 6.2 rebounds, and 1.2 blocks per game while shooting an absurd 76.6 percent from the floor.
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Ball movement has been another key for Louisville, as the Cardinals average 19.2 assists per game. Mikel Brown Jr. runs the offense smoothly with 5.3 assists per game, and Louisville’s depth allows consistent scoring pressure for all 40 minutes. Recent wins over Indiana and at Arkansas reinforce how comfortable this team looks against quality opponents.
Louisville vs Memphis Pick
The matchup heavily favors Louisville, especially at home. Memphis will need an unusually turnover-free offensive game to hang around, and that feels unlikely given the Cardinals’ overall better talent. Louisville to win straight up is the safest angle. The Cardinals’ point differential and home dominance point toward a comfortable victory. A lean toward the over also makes sense, with Louisville pushing pace and Memphis capable of contributing enough to keep the total moving. Final score prediction: Louisville 88, Memphis 70. Check out all the sportsbook promos to see if you are getting a great deal on your bets on Memphis. Make sure you know about how the fans are looking on prediction markets for Louisville with the Kickr promo code. Make sure when you place your bet on Louisville vs Memphis you are using the BetMGM bonus code.
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