Oregon Ducks vs USC Trojans Picks & Prediction for Saturday, February 21, 2026

By: Thomas Pemberton Published 02/21/2026, 02:40 AM ET

The Oregon Ducks head to USC to take on the Trojans in this Big 10 matchup. USC beat Oregon 82-77 in their last meeting back in December. Both Oregon and USC are coming off losses and are hungry to get back into the win column. Tipoff is set for 4:00 PM est at the Galen Center. Don't miss another free pick. Find all of our expert's Free College Basketball Picks Here.

Ducks Have Been Bad On The Road

The Oregon Ducks are 9-17 on the season with a 1-6 road record. Oregon has won just one of their last ten games. The Ducks lost to Minnesota 61-44 in their last game played. Oregon scored just 17 points in the first half of the loss. Nate Bittle led the way with 15 points and 7 rebounds. Bittle leads Oregon on the season with 16.8 points scored per game. Oregon is scoring 71.2 points scored per game with 8.1 made three pointers. The Ducks have four players averaging double digit points scored per game.

Trojans Hoping To Avoid Three Straight Losses

The USC Trojans head into Saturday riding a two game losing streak. USC lost to #10 Illinois 101-65 in their last game played. The Trojans were outscored 52-32 in the first half of the loss. Ezra Ausar led the way in the loss with 15 points and 11 rebounds. Ausar is averaging 15.7 points scored per game. USC is 18-8 on the season with a 9-4 home court record. The Trojans have won five of their last ten games. USC is scoring 80.7 points per game with 6.3 made three pointers.

Oregon vs USC Spread Pick

USC Trojans -6

The USC Trojans are hoping to knock off Oregon for a second time this season. USC has lost two straight games but Oregon has been absolutely awful on the road. The Trojans are 13-12 against the spread on the season. Oregon is 2-5 against the spread on the road this season. Watch for USC to be the better team at home.

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

Oregon vs USC Over/Under Pick

OVER 146.6

The over/under is set at 146.5 points in this matchup. Oregon is coming off of one of their worst offensive showings of the season in their last game. Watch for the Ducks to be more disciplined with high percentage shots. USC plays their best ball at home and will be hungry to snap their two game losing streak.

Betting on College Basketball?

Join Picks and Parlays premium for free and get a free $30 coupon with code FREE30
Get started and wager on college hoops today with our favorite online sportsbooks
Claim a CBB betting bonus offer with the best sportsbook promos

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.

Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelplineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-HOPENY or text HOPENY (467369) (NY). 21+ (18+ DC, IA, KY, WV) only. New users only or text HOPENY (467369) (NY). Casino, First online real money wager only. $5 first deposit required. Min $5 wager required for 5 consecutive days. Bonus issued as non-withdrawable Bet Reset tokens. Refund from token issued as nonwithdrawable bonus bet that expire 7 days after receipt. Max refund $200 per day. Restrictions apply, including token expiration. See full terms at fanduel.com/sportsbook. Call 1-877-770-7867 (LA).

Min. Deposit $5

Odds Requirements -500

Cashable No

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 7/19/26 at 11:59 PM ET. Sponsored by DK.