San Francisco at Saint Louis — Picks & Prediction for Saturday, December 13, 2025
The San Francisco Dons travel to St. Louis to take on the Saint Louis Billikens on Saturday, December 13, 2025. Get in on the action with our free college basketball picks.
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San Francisco Dons Analysis
San Francisco comes into this matchup having just earned a road win over Mississippi State, grabbing a 65-62 victory in their last outing thanks to strong rebounding and solid defense.
Key Team Metrics & Style
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Record: 6-4 overall, 0-1 away.
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Scoring & Efficiency: USF averages ~75 points per game, with Ryan Beasley leading at about 13.0 PPG, while Mookie Cook contributes about 11.7 PPG.
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Rebounding: They secure around 38 rebounds per game, but defensive rebounding is a pressure point — 25.4 defensive boards per game, below what Saint Louis gets.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Tony Karpinski | +2,389.00 |
| 2 |  Joe Duffy | +1,960.00 |
| 3 |  The Insiders Room | +1,788.00 |
| 4 |  Terry Edelmann | +1,748.00 |
| 5 |  Mike Fink | +1,583.00 |
Strengths
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Balanced scoring: Four players average close to double figures, giving them offensive options and spacing.
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Recent momentum: A tight road win over Mississippi State shows the Dons can close on the road when locked in.
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3-point prowess: San Francisco leads the WCC in made triples per game, making them dangerous from range.
Weaknesses / Risks
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Rebounding deficit vs. elite boards: With Saint Louis averaging over 40 rebounds per game, U.S.F. could be overwhelmed on the glass.
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Road struggles and hostile environment: A 0-1 road mark and the challenge of Chaifetz Arena’s crowd could sap confidence early.
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Defense vs high-tempo offense: Saint Louis pushes pace, a tough test for San Francisco’s transition and perimeter containment.
Saint Louis Billikens Analysis
Saint Louis looks like one of the country’s most prolific offenses early, combining scoring balance with rebounding dominance and efficient defense.
Team Strengths & Style
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Record: 8-1 overall, 6-0 at home.
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Scoring: They lead the nation in scoring, averaging about 91.6 points per game on offense.
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Rebounding & Defense: Saint Louis is top-tier in rebounding margin (+12.9) and allows only about 37.2% shooting on defense.
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Balanced Attack: Robbie Avila and Dion Brown each average ~12.4 PPG, with Trey Green, Amari McCottry, and Quentin Jones also chipping in.
Strengths
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Home dominance: A perfect home record and comfortable role as A-10 leader gives them confidence and crowd support.
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Offensive variety: They can score inside and out, big and small, thanks to rotation depth and balanced scoring.
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Rebounding control: Their rebounding edge should limit second-chance opportunities for San Francisco.
Weaknesses / Risks
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Turnovers can hurt: High-tempo offenses sometimes trade possessions; careless ball security could allow San Francisco easy shots.
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Pressure to sustain scoring: Against disciplined defenses, they must maintain efficiency and shot selection.
Standout Players & Key Matchups
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San Francisco:
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Ryan Beasley — lead scorer and facilitator, can create his own shot and push tempo.
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Mookie Cook — secondary scorer and versatile rebounder, gives USF physicality.
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Saint Louis:
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Robbie Avila — scoring and playmaking leader, key to tempo and offensive rhythm.
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Dion Brown — top rebounder and efficient scorer, anchors their inside game.
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Saint Louis vs San Francisco Prediction Reasoning
This game features a contrast in styles — San Francisco’s balanced scoring and perimeter shooting against Saint Louis’s elite offense, rebounding, and home strength. Saint Louis’s ability to control tempo, rebound, and score in bunches makes them a tough matchup, especially in front of a supportive home crowd. San Francisco’s balanced attack and recent road win gives them tools to compete, but the Billikens’ depth and efficiency should prevail late. The best sportsbooks are the best way to go when you are betting on Saint Louis. Make sure you know about how the fans are looking on prediction markets for San Francisco with the Onyx Odds promo code. Getting the most out of your bets on Saint Louis vs San Francisco can be done by using the Fanatics Sportsbook promo code.
Final Score Projection: Saint Louis 92, San Francisco 80
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- Saint Louis -10.5
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