Villanova vs DePaul Picks and Predictions For Wednesday March 4 2026

By: Jeremy O'Quinn Published 03/04/2026, 02:20 AM ET
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Villanova Preview

The Villanova Wildcats are heading to Wintrust Arena on Wednesday, where they will take on the DePaul Blue Demons. Get the rest of our free college basketball picks here! The Villanova Wildcats enter this Big East Conference matchup with a 22-7 overall record and a 13-5 mark in league play, giving them one of the stronger résumés in conference action. Villanova has been averaging 77.2 points per game while allowing 70.8 points per contest. The Wildcats have shown they can score in bunches. Villanova has been mediocre defensively, sitting with a 107.3 defensive rating.

DePaul Preview

The DePaul Blue Demons currently sit at 16-13 overall and 8-10 in Big East play, riding some late-season momentum with multiple close victories, including an impressive 72-71 road win vs Creighton and a 62-51 victory over Marquette in their last five games. DePaul has been averaging 71.2 points per game while allowing roughly 69.2 points per contest, a profile that shows slightly below-average offensive output but respectable defense compared to many Big East teams. The Blue Demons don’t typically overwhelm opponents scoring-wise, but they’ve been competitive and have tightened up their defense. DePaul ranks 81st in the NCAA with a 104.6 defensive rating heading into Wednesday.

DePaul vs Villanova Prediction

DePaul will be on the hunt for a third straight win on Wednesday, while Villanova looks for a bounce back win. Exact Villanova to come out aggressive and cover the -3.5 spread in this one. Final score prediction, Villanova wins 78-72.

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