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Villanova vs La Salle Picks and Prediction for Wednesday, November 19, 2025

By: Jake Allman Published 11/19/2025, 12:10 AM ET

Villanova heads into John Glaser Arena at 3-1 and riding a three-game win streak, and the Wildcats look sharp on both ends. They are scoring 85.3 points per game while shooting 46 percent, and Bryce Lindsay’s 23.0 points per game lead the way. Wins over Duquesne, Seton Hall, and Quinnipiac show a team that has started the new season on the right foot. Duke Brennan’s 14.8 rebounds per game have also made a clear impact by creating extra possessions. March isn’t the only madness — today’s college basketball picks are ready to cash.

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Villanova Preview

Momentum is trending in the right direction for Villanova thanks to steady backcourt play. Acaden Lewis averages 5.3 assists and shoots well, while Lindsay hits 50 percent from deep. Villanova shoots 37.3 percent from three as a team with 18 assists per game, a sign of strong ball movement and good shot quality. The 41.8 rebounds per game also allow them to control the pace and limit opponents’ transition chances, which is key on the road. Make sure you know about how the fans are looking on prediction markets for Villanova with the Thrillz promo code.

La Salle Preview

La Salle sits at 2-2 with two home wins, but the losses to Penn State and Temple exposed inconsistency. The Explorers average 73 points per game on 42.9 percent shooting, and the offense relies heavily on Jaeden Marshall’s 15.3 points. Jerome Brewer Jr. chips in 11.5 points with solid shooting, and Ashton Walker adds 9.8 points and 5.5 assists. La Salle has played harder at home, but the recent losses showed they can struggle when opponents spread the floor and move the ball. Make the most of your bets on La Salle by using the sportsbook promos.

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La Salle vs Villanova Prediction

Matching Villanova’s shooting is the biggest concern for La Salle. The Explorers pull down only 36 rebounds per game, which creates issues against Villanova’s size. The 12.8 turnovers per game are manageable, but Villanova averages seven steals and can turn mistakes into momentum swings. La Salle shoots 39.7 percent from three, which can keep them competitive if they stay hot, though relying on that alone is risky. Make sure when you place your Villanova vs La Salle bet you are using the bet365 bonus code.

Prediction: Villanova’s depth, shooting edge, and rebounding advantage make the difference. The Wildcats stay in control throughout. Villanova 82, La Salle 70

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Best Pick

  • Villanova -8.5 The matchup lines up cleanly for Villanova, who holds advantages in scoring efficiency and interior play.
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