Virginia vs Northwestern Picks and Predictions for Friday, November 21, 2025

By: David Anicetti Published 11/21/2025, 12:45 AM ET

Virginia meets Northwestern in the Greenbrier Tip-Off Mountain Division on Friday, with both teams at 4–0. The Cavaliers are coming off a 104–78 win over Marshall, while the Wildcats edged DePaul 81–79 for their fourth straight victory. Both teams have opened the season with strong defense and solid scoring. Play your ticket and cash in with college basketball picks.

Game Information for Virginia vs Northwestern

  • Date & Time: Friday, November 21, 5:00 PM ET
  • Where: Colonial Hall, White Sulphur Springs, WV
  • TV: CBSSN

Virginia Cavaliers Outlook

Virginia is averaging 90.8 points per game on 50% shooting while grabbing 46.0 rebounds and handing out 19.0 assists. Thijs De Ridder leads the Cavaliers with averages of 17.3 points and 6.0 rebounds while shooting 54.2%. Malik Thomas adds 12.0 points per game, and Chance Mallory has averaged 10.3 points, 3.0 assists, and strong perimeter shooting.

Defensively, the Cavaliers are giving up 61.5 points per game while making 8.3 steals and 7.3 blocks. Center Johann Grunloh has anchored the paint with 7.5 rebounds and 4.3 blocks per game, while Ugonna Onyenso averages  2.5 blocks. Virginia’s combination of rim protection and perimeter defense has allowed it to control opponents. Wins over Marshall, Hampton, North Carolina Central, and Rider have come by wide margins thanks to pressure defense and a solid offense. The best sportsbooks are the best way to go when you are betting on Virginia.

Northwestern Wildcats Outlook

Northwestern is averaging 84.3 points per game while shooting 52.2% from the field. Nick Martinelli leads the team with an average of 20.5 points per game on 62.2% shooting, and Arrinten Page adds 16.0 points and 8.3 rebounds while making 66.7% of his shots. Guard Jayden Reid contributes 12.0 points and 5.8 assists, giving the Wildcats a backcourt playmaker. Northwestern also shares the ball well, matching Virginia with 19.0 assists per game.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

The Wildcats are allowing 60.3 points per game and making 7.5 steals with 4.5 blocks. Page has been a key defender with strong rebounding and shot contesting, while Max Green, Justin Mullins, and Reid have played defense well on the perimeter. Northwestern has handled its schedule comfortably, with home wins over Cleveland State, Boston University, and Mercer before its road win at DePaul. Make sure you know about how the fans are looking on prediction markets for Northwestern with the Onyx Odds promo code.

Virginia vs Northwestern Prediction

Both teams have strong scoring and defense, but Virginia’s interior strength and rim protection give the Cavaliers the advantage on a neutral floor. Northwestern’s scoring will keep this competitive, but Virginia’s ball movement and defensive presence inside will make the difference on Friday. Final Score Prediction: Virginia Cavaliers win and cover ATS, 81–73. Getting the most out of your bets on Virginia vs Northwesstern can be done by using the Fanatics Sportsbook promo code.

Betting on College Basketball?

BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $150 in Bonus Bets *Paid Within 14 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Cashable No
Video: Dodgers vs Diamondbacks, Athletics vs Red Sox & Rays vs Mariners | MLB Picks
Dodgers vs Diamondbacks, Athletics vs Red Sox & Rays vs Mariners | MLB Picks
Video: Phillies vs Nationals | MLB Picks | Chip Chirimbes
Phillies vs Nationals | MLB Picks | Chip Chirimbes

Best Picks

  • Virginia
  • Over
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright © 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.