Auburn vs Oklahoma Picks and Predictions for Saturday, September 20, 2025
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It's Auburn vs Oklahoma as two CFB juggernauts square off on Saturday at 3:30 p.m. ET at Memorial Stadium in Norman.
Both teams are 3–0. Auburn comes off wins over South Alabama, Ball State, and at Baylor. Oklahoma has handled Illinois State, Michigan, and Temple.
See below for our Auburn vs Oklahoma prediction, and follow all NCAAF action this weekend with our college football picks.
Auburn Preview
Quarterback Jackson Arnold is off to a strong start: 48 of 69 for 501 yards with four touchdowns and no picks. The ground game is led by Jeremiah Cobb with 314 yards on 46 carries with four TDs. Auburn has 726 rushing yards and 10 rushing TDs as a team. Eric Singleton leads all receivers for the Tigers with 13 receptions for 149 yards and a pair of touchdowns.
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The front seven has been active. Keyron Crawford has 3.0 sacks and a team-high 16 tackles, and several linebackers have chipped in more pressure. That surge up front helps set up solid field position for the Auburn offense. The defense is playing well, but the concern is pass protection (six sacks allowed so far) from the offensive line.
Oklahoma Preview
Quarterback John Mateer has been productive: 944 yards, 5 TD, 67.6% completions, and has 161 rushing yards with four rushing TDs. The receivers are led by Jaren Kanak with 245 yards, while Deion Burks has 225 yards and two touchdowns. Oklahoma doesn’t need big runs to move the chains since the passing attack is hitting on all cylinders.
Defensively, Sammy Omosigho paces the team with 14 tackles, and the Sooners have spread sacks across the front seven. The unit held Michigan to 13 and Temple to 3, tackling well in space and limiting big plays. The key here is to control the early downs and limit quarterback runs, forcing Auburn to throw into tighter coverage.
Auburn vs Oklahoma Prediction
Oklahoma will win a close game. The Sooners’ passing and balanced red-zone success give them a slight edge at home. Auburn’s rush attack will keep the Tigers close in a lower-scoring game, but Oklahoma’s third-down passing will be the difference. Final Score Prediction: Oklahoma Sooners win and cover ATS 27-17.
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Best Pick
- Oklahoma Sooners -5.5
