Buffalo at Central Michigan Picks and Predictions for Wednesday, November 12, 2025

By: David Anicetti Published 11/09/2025, 10:31 PM ET
Use Code PPWC

The Buffalo Bulls (5–4, 4–1 Mid-American Conference) visit the Central Michigan Chippewas (5–4, 3–2 MAC) in a game that could shape the MAC standings. Buffalo handled Bowling Green 28–3 last week, while Central Michigan fell 24–21 at Western Michigan. Buffalo is currently 2nd in the conference, while Central Michigan is 5th. Score the winning touchdown with our college football picks.

Buffalo at Central Michigan Game Information

Kickoff: 7:00 PM ET, November 12

Where: Kelly/Shorts Stadium, Mount Pleasant, MI

TV: ESPN2

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Buffalo Bulls Preview

Quarterback Ta’Quan Roberson has passed for 1,739 yards with 12 touchdowns and eight interceptions, completing 60.5% of his throws. Nik McMillan leads the receivers with 590 yards, and Victor Snow has added 586 yards with seven touchdowns. Running back Al-Jay Henderson has rushed for 663 yards and five scores on 161 carries, averaging just over 4 yards per carry. Buffalo’s offense has topped 28 points in three of its last five games.

Linebacker Red Murdock leads the Bulls with 105 tackles and 4.5 sacks. Malin White has three sacks, while corner Jalen McNair has two interceptions. Buffalo’s defense has improved over the last month, holding Bowling Green and UMass to a combined 24 points. Jack Howes has converted 10 of 13 field goals with a long of 50 yards and is perfect on extra points.

Central Michigan Chippewas Preview

Quarterback Joe Labas has thrown for 1,066 yards with eight touchdowns and two interceptions, completing 71.6% of his passes. Angel Flores complements him with 519 rushing yards and eight touchdowns, while Nahree Biggins adds 426 yards on the ground. Langston Lewis leads the team with 295 receiving yards and two touchdowns, and Tyson Davis has contributed 181 yards and two scores. Central Michigan has been solid in the red zone, scoring on 15 of its last 17 trips.

Linebacker Jordan Kwiatkowski leads the defense with 70 tackles, and Michael Heldman has produced 5.5 sacks. Defensive back Brenden Deasfernandes has two interceptions, and the Chippewas have forced seven turnovers over the last four games. Cade Graham has been consistent on special teams, hitting 12 of 14 field goals with a long of 47 yards.

Buffalo at Central Michigan Prediction

Central Michigan will move the ball with its mix of passing from Labas and runs from Flores. Buffalo’s defense will keep it close early, but Central Michigan’s balance on offense and defensive pressure will separate the teams in the second half. Final Score Prediction: Central Michigan Chippewas win and cover ATS, 23–17.

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Best Picks

  • Central Michigan Chippewas -2.5
  • Under 43.5
  • Angel Flores Anytime Touchdown
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