Buffalo vs Massachusetts Picks and Prediction for Saturday, October 18, 2025

By: Cameron Ross Updated 10/17/2025, 09:14 PM ET
Use Code PPWC

Buffalo vs Massachusetts Information

The Buffalo Bulls return to the road this week with a game in Warren McGuirk Alumni Stadium at 2:30 PM against the Massachusetts Minutemen. Buffalo has three wins and three losses on the year coming into this game, following a one-point overtime victory against Eastern Michigan last time out. Massachusetts will be back on its home field this week as one of the worst teams in the country, winless through six games played this season. Stay in the loop with our College Football Picks.

Test drive our top experts for an entire week β€” completely free. Enjoy 7 days of Flex Picks on us, discover new cappers daily, and see who matches your betting style. Use coupon code FREE7 to unlock access. [CLAIM NOW]

Buffalo Preview

Offensively, Buffalo has been solid this season, averaging 25.6 points per game overall. Defensively, Buffalo is allowing 21.3 points per game this season. Ta’Quan Roberson has carried the Buffalo offense this season with 934 yards and eight scores on 78 completions. Al’Jay Henderson leads the team with 418 yards and four touchdowns on 112 carries. Victor Snow is the top receiver on the roster with 29 catches for 410 yards and five scores.

Massachusetts Preview

Offensively, Massachusetts has been terrible this year, averaging just 9.6 points per game overall. Defensively, Massachusetts is allowing 36.8 points per game this season through six games played. AJ Hairston leads the Massachusetts offense this season with 517 yards and one score on 55 completions. Rocco Griffin is the top ball carrier with 166 yards and one touchdown on 35 carries. Jacquon Gibson leads the team with 358 yards on 36 catches.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Buffalo vs Massachusetts Prediction

Buffalo is the far better team in this matchup, and it will show from the opening minutes this week. Look for the Bulls to dominate this game on both sides of the ball against the worst team in the conference. Take Buffalo to continue their winning ways as they give Massachusetts another loss following the win and cover on the road. Final Score Prediction, Buffalo Bulls win and cover 38-13.

Betting on College Football?

BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No
Video: World Cup: Mexico vs England BEST Bets & Predictions | July 5, 2026
World Cup: Mexico vs England BEST Bets & Predictions | July 5, 2026
Video: Brazil vs Norway: The Bet You AREN'T Thinking Of! | BEST World Cup Predictions | July 5, 2026
Brazil vs Norway: The Bet You AREN'T Thinking Of! | BEST World Cup Predictions | July 5, 2026

Best Picks:

  • Buffalo Bulls -16.5
  • Over 44.5
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.