Buffalo vs Penn State Picks and Predictions for Saturday, September 19th, 2026

By: Cameron Ross Published 09/18/2026, 11:02 PM ET

Buffalo vs Penn State Game Information

The Buffalo Bulls will be on the road Saturday for a 12:00 PM game inside Beaver Stadium against the Penn State Nittany Lions. Buffalo enters the matchup at 1-1 after losing to Florida International by 13 points last week. Penn State remains undefeated following an 18-point victory over Temple. Β Stay in the loop with our College Football Picks.

Buffalo Preview

Elijah Holmes leads the Buffalo offense this season with 250 yards and 3 touchdowns on 35 completions. Jason Wright has also seen significant action, throwing for 185 yards and 2 scores on 13 completions. Messiah Burch leads Buffalo with 90 yards on 18 carries, while Terrance Shelton Jr. has added 75 yards on 22 attempts. Holmes has added another 23 yards on 10 carries from quarterback. Chance Morrow has carried the Buffalo passing attack with 218 yards and 5 touchdowns on 18 catches. Clint Walker and Trevor Wilson have each added 46 receiving yards, while Jaylen Andrews has contributed 39 yards on 6 grabs.

Penn State Preview

Rocco Becht is leading Penn State this season with 539 yards and 7 touchdowns on 34 completions. Carson Hansen leads the Nittany Lions on the ground with 132 yards on 30 carries. James Peoples has added 73 yards on 15 attempts, while Cam Wallace has recorded 44 yards and 1 score on 12 carries. Koby Howard leads the Penn State receiving corps with 229 yards and 1 touchdown on 9 catches. Chase Sowell has contributed 91 yards and 1 score on 7 receptions. Benjamin Brahmer has been a dependable red-zone target with 87 yards and 3 touchdowns on 6 grabs, while Zay Robinson has added 73 yards and 1 score on 4 catches.

Buffalo vs Penn State Pick

Penn State has dominated its first 2 opponents, allowing only 9 total points while scoring 72. Buffalo has some ability through the air, but the Bulls struggled against Florida International and now face much tougher competition. The Nittany Lions should apply steady pressure to both Buffalo quarterbacks and prevent Morrow from creating big plays downfield. Becht has been highly efficient and should take advantage of a Buffalo defense that surrendered 33 points last week. Look for Penn State to score early, create multiple turnovers, and cruise to another comfortable home victory.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.
  • Pick: Penn State -40.5
  • Secondary: Over 49.5

Final Score Prediction: Penn State 52, Buffalo 7

Betting on College Football?

BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Get $350 in Bonus Bets when you wager $5 for 7 days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Get $350 in Bonus Bets when you wager $5 for 7 days ($50 Bonus Bets per day)
Cashable No
DraftKings Sport

New DraftKings Customer: SPEND $5, GET $200 IN BONUSES

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Requirement New DraftKings Customer Offer: SPEND $5, GET $200 IN BONUSES ($50 in Bonus Bets every 7 days for 21 days)*
Cashable No
Video: Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Video: Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview
Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, Massachusetts, New York, Ontario, or Puerto Rico.