Central Michigan vs Pittsburgh Picks and Predictions, September 6, 2025

By: David Anicetti Published 09/01/2025, 11:28 PM ET

Central Michigan Preview

The Central Michigan Chippewas visit Acristure Stadium in Pittsburgh, PA Saturday to play the Pittsburgh Panthers. Central Michigan is 1-0 following its 16-14 victory on the road over San Jose State on Friday night. Central Michigan gained 340 yards of total offense, including 225 rushing, averaging 4.3 yards per carry on 52 carries. Cade Graham made 3-of-4 field goal attempts. Keep up to date with all the college football action with our college football previews.

Central Michigan quarterback Angel H Flores had 59 yards passing, and Joe Labas passed for 56 yards. The leading rusher is Nahree Biggins with 102 yards, while Trey Cornist has 99 rushing yards and one touchdown. Tommy McIntosh is the leading receiver with 61 yards. Defensive back Kalen Carroll has a team-high of seven tackles. Central Michigan has one sack and two interceptions.

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Pittsburgh Preview

The Pittsburgh Panthers opened their regular season on Saturday with a 61-9 rout of the Duquesne Dukes. Pittsburgh generated 460 yards of total offense, and the Panthers’ defense held Duquesne to just 212 yards of total offense. Pittsburgh had 21 first downs to only 8 by Duquesne. The Panthers allowed Duquesne to convert only two of its 15 third-down attempts.

Pittsburgh quarterback Eli Holstein has thrown for 215 yards with four touchdowns and one interception. Backup Cole Gonzales has 87 yards passing and one touchdown. Desmond Reid is the leading rusher with 66 yards and one touchdown, while Bryce Yates is the leading receiver with 69 yards and one touchdown reception. Pittsburgh's defense has four quarterback sacks but no interceptions.

Central Michigan vs Pittsburg Pick

Central Michigan won its season opener but faces a much more talented squad in Pittsburgh on Saturday. Pittsburgh routed Duquesne in its season-opener, with its defense controlling the line of scrimmage. Central Michigan’s defense looked tough in its win, but Pittsburgh’s offense uses a balanced attack and will keep the Chippewas on their heels throughout. Final Score Prediction: Pittsburgh Panthers win and cover ATS 37-10.

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