Charlotte vs Ole Miss Picks and Predictions for Saturday, September 12th, 2026

Charlotte vs Ole Miss Game Information

The Charlotte 49ers will travel to Oxford Saturday night for a 7:45 PM ET matchup against the Ole Miss Rebels inside Vaught-Hemingway Stadium. Charlotte comes into week 2 of the year winless this season following a 2-point triple-overtime loss to The Citadel a week ago. The Ole Miss Rebels stay home Saturday, ranked #9 in the country and undefeated this year, after a narrow 3-point victory against Louisville last week. Stay in the action with our College Football Picks.

Charlotte Preview

Offensively, Charlotte was phenomenal a week ago, scoring 41 points on 538 total yards, but turned the ball over twice, leading to the loss. Defensively, Charlotte had a ton of trouble, giving up 400 yards and 43 points, including 15 in overtime. Cole Gonzales led the Charlotte offense a week ago, completing 28 passes for 322 yards and 3 touchdowns, and ran the ball 6 times for 31 yards and 2 scores. Khamani Alexander led the way on the ground for Charlotte with 138 yards and 1 touchdown on 14 carries. Jaylen Hampton was the top target in the Charlotte offense with 117 yards and 2 touchdowns on 8 receptions.

Ole Miss Preview

The Ole Miss offense was phenomenal last week, scoring 41 points, including 31 in the second half, on 488 yards. Defensively, Ole Miss did have some trouble, giving up 38 points on 469 total yards of offense. Trinidad Chambliss carried the Ole Miss offense last week with 21 completions for 336 yards and 3 scores and ran the ball 9 times for 60 yards and 1 touchdown. Kewan Lacy was the top ball carrier on the roster with 61 yards and 1 touchdown on 17 carries. Deuce Alexander led the team with 159 yards and 2 touchdowns on 5 catches, and Caleb Odom added 3 catches for 61 yards and 1 score.

Charlotte vs Ole Miss Pick

Ole Miss is the far better team in this matchup and will ride their wave from last week's victory. Look for Ole Miss to jump on Charlotte early in this game, setting the tone. Take Ole Miss to use its depth and talent all over the field to control this game, leading to a blowout win and cover for their 2^nd win of the year.

• Pick: Ole Miss Rebels -45.5
• Secondary: Over 59.5

Final Score Prediction: Ole Miss Rebels win and cover 56-7

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