Coastal Carolina vs Charleston Southern Picks and Prediction for Saturday, September 6, 2025
Coastal Carolina hosts Charleston Southern in Week 2 on Saturday, September 6, 2025, at Brooks Stadium in Conway, S.C. Kickoff is set for 7:30 PM ET. Coastal Carolina, reeling from a 48–7 road loss at Virginia, seeks redemption. Charleston Southern also suffered a decisive loss in Week 1 and looks to regroup behind their returning veteran quarterback. The Coastal Carolina vs Charleston Southern game is not the only one on the week, so make sure you check out all of our college football picks.
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Coastal Carolina Analysis
Coastal Carolina enters the contest at 0–1 following a heavy 48–7 defeat at Virginia . On both sides of the ball, the Chanticleers are searching for rhythm, particularly with a new offensive coordinator installing an Air Raid scheme under head coach Tim Beck Coastal Carolina was picked to finish fourth in the Sun Belt East in preseason polling, with optimism centered around offensive line standout Nick Del Grande and WR Jameson Tucker, who earned All-Conference preseason recognition.
Charleston Southern Analysis
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +2,098.00 |
| 2 |  Ross Benjamin | +1,205.00 |
| 3 |  Chip Chirimbes | +1,045.00 |
| 4 |  Dan Kaiser | +825.00 |
| 5 |  Arthur Reyes | +472.00 |
Charleston Southern also stands at 0–1, having struggled in both offense and defense in the lone game thus far. Historically, the Buccaneers have found early-season matchups against FBS teams difficult—going 0–5 SU in their last five road openers. They’re guided by a bend-but-don’t-break defense and returning QB Zolten Osborne, who brings leadership and experience, though offensive weapons are limited post-transfer.
Standout Players and Key Injuries
For Coastal Carolina, the offensive line led by preseason All-Sun Belt pick Nick Del Grande anchors hopes for effective run and pass protection. Wide receiver Jameson Tucker also figures prominently as a deep threat. Defensively, linebacker Shane Bruce offers toughness and versatility. Charleston Southern relies on veteran QB Zolten Osborne to steer the offense and linebacker Steve Zayachkowsky to provide leadership on defense. No significant injuries have been reported, but offensive depth is a known issue for the Buccaneers.
Prediction Reasoning
This matchup sets up as a predictable FBS vs. FCS game. While Coastal Carolina is still finding its offensive identity and came off a tough loss, their overall depth, talent level, and home-field advantage will likely overwhelm Charleston Southern. The Buccaneers' offensive limitations and Coastal’s preseason talent recognition suggest a comfortable Chanticleers win.
Final Score Projection: Coastal Carolina 41, Charleston Southern 13
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