Coastal Carolina vs Charleston Southern Picks and Prediction for Saturday, September 6, 2025

By: Garrett Beaverson Published 09/02/2025, 03:52 PM ET

Coastal Carolina hosts Charleston Southern in Week 2 on Saturday, September 6, 2025, at Brooks Stadium in Conway, S.C. Kickoff is set for 7:30 PM ET. Coastal Carolina, reeling from a 48–7 road loss at Virginia, seeks redemption. Charleston Southern also suffered a decisive loss in Week 1 and looks to regroup behind their returning veteran quarterback. The Coastal Carolina vs Charleston Southern game is not the only one on the week, so make sure you check out all of our college football picks.

Coastal Carolina Analysis

Coastal Carolina enters the contest at 0–1 following a heavy 48–7 defeat at Virginia . On both sides of the ball, the Chanticleers are searching for rhythm, particularly with a new offensive coordinator installing an Air Raid scheme under head coach Tim Beck Coastal Carolina was picked to finish fourth in the Sun Belt East in preseason polling, with optimism centered around offensive line standout Nick Del Grande and WR Jameson Tucker, who earned All-Conference preseason recognition.

Charleston Southern Analysis

Charleston Southern also stands at 0–1, having struggled in both offense and defense in the lone game thus far. Historically, the Buccaneers have found early-season matchups against FBS teams difficult—going 0–5 SU in their last five road openers. They’re guided by a bend-but-don’t-break defense and returning QB Zolten Osborne, who brings leadership and experience, though offensive weapons are limited post-transfer.

Standout Players and Key Injuries

For Coastal Carolina, the offensive line led by preseason All-Sun Belt pick Nick Del Grande anchors hopes for effective run and pass protection. Wide receiver Jameson Tucker also figures prominently as a deep threat. Defensively, linebacker Shane Bruce offers toughness and versatility. Charleston Southern relies on veteran QB Zolten Osborne to steer the offense and linebacker Steve Zayachkowsky to provide leadership on defense. No significant injuries have been reported, but offensive depth is a known issue for the Buccaneers.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Prediction Reasoning

This matchup sets up as a predictable FBS vs. FCS game. While Coastal Carolina is still finding its offensive identity and came off a tough loss, their overall depth, talent level, and home-field advantage will likely overwhelm Charleston Southern. The Buccaneers' offensive limitations and Coastal’s preseason talent recognition suggest a comfortable Chanticleers win.

Final Score Projection: Coastal Carolina 41, Charleston Southern 13

Best Bets

A broad list of handicappers publishing premium picks across NFL, NBA, CBB, NHL, CFL, and soccer, including Rob Vincilleti, Ben Burns, Mike Lundin, Sean Higgs, Ross Benjamin, and algorithmic teams like Advanced Sports AI.

Ben Burns Billy Coleman Bruce Marshall Bryan Power Chip Chirimbes David Delano David Hess Jackie Mack Jesse Schule Joe Duffy Joseph D'Amico Marc David Mark Ruelle Mark Zinno Mike Fink Mike Lundin Nick Parsons Pro Sports Picks Razor Ray Monohan Ricky Tran Rob Vinciletti Rocky Atkinson Ross Benjamin Sean Higgs Sniper Wes Stephen Nover Steve Seagrave Terry Edelmann The Gold Sheet Tom Macrina Tony Karpinski Trent Bets Will Rogers
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Follow us

Copyright © 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.