Delaware vs Colorado Picks and Prediction for Saturday, September 6, 2025

By: Cameron Ross Updated 11/18/2025, 04:54 PM ET

Delaware Preview

The Delaware Blue Hens will play their first road game of the season this week with a game in Boulder against the Colorado Buffaloes. Delaware is undefeated coming into this game following their 18-point victory in week one. Offensively, Delaware controlled their week 1 matchup against Delaware State, scoring 35 points, including 21 in the second half, on 409 total yards. Defensively, Delaware did just enough, giving up 17 points on 349 yards, but forced multiple turnovers to seal the victory. Stay in the action with our College Football Picks.

Nick Minicucci carried the load for the Delaware offense in week 1, completing 28 passes for 251 yards and three touchdowns, and added a team high 44 yards and one touchdown on 9 carries. Jake Thaw led the team with 92 yards and one touchdown on 7 receptions. Kyre Duplessis chipped in seven catches for 89 yards and one score, while Ja’Carree Kelly added 22 yards and one touchdown on 2 catches.

Colorado Preview

The Colorado Buffaloes stay at home this week, winless on the year, following a 7-point loss against Georgia Tech in the season opener. Offensively, Colorado scored 20 points on 305 total yards, but converted just five third downs, resulting in the loss. Defensively, Colorado was outmatched as Georgia Tech scored 27 points on 463 total yards.

Kaidon Salter carried the load for the Colorado offense in week 1, completing 17 passes for 159 yards and one score. Michael Welsh led the team with 64 yards on 11 carries. Quarterback Kaidon Salter chipped in 13 carries for 43 yards and one score in the game period. Omarion Miller led the team with 39 yards on one catch, and Dekalon Taylor chipped in three catches for 38 yards and one touchdown.

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Delaware vs Colorado Pick

Despite the loss in week 1, Colorado will get back on track in week two. Look for the Buffaloes to clear the issues this week as they get a win against Delaware. Take Colorado this week to get the winning cover at home following a loss in week one. Final Score Prediction, Colorado Buffaloes win and cover 42-7.

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