Duke vs Virginia Picks and Predictions for Saturday, December 6, 2025
Duke vs Virginia Information
The Duke Blue Devils will be in Charlotte, NC, this week for an 8:00 PM matchup against the Virginia Cavaliers in the ACC championship at Bank of America Stadium. Duke has seven wins and five losses this season, but comes into this week having won three of the last five, including two in a row after a 17-point home victory over Wake Forest. The Virginia Cavaliers are the 18th-ranked team in the nation with 10 wins and 2 losses overall, having won 4 of the last 5, including 2 in a row after a 20-point victory over Virginia Tech last time out. Stay in the news with our College Football Picks.
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Duke Preview
Darian Mensah leads the Duke offense this season with 3450 yards and 28 touchdowns on 286 completions. Nate Shepard is the top ball carrier with 865 yards and 9 scores on 157 carries this season. Anderson Castle has added 94 carries for 435 yards and 11 scores this season. Cooper Barkate is the top target on the roster with 978 yards and six touchdowns on 63 catches this season. Make sure you know about how the fans are looking on prediction markets for Duke with the Thrillz promo code.
Virginia Preview
Chandler Morris leads the Virginia offense this season with 2586 yards and 14 touchdowns on 236 completions to go along with 248 and 5 scores on 55 carries this season. J’Mari Taylor leads the way on the ground for Virginia this season with 997 yards and 14 touchdowns on 207 carries. Trell Harris is the top receiver on the team with 809 yards and five touchdowns on 56 receptions. Make the most of your bets on Virginia by using the sportsbook promos.
Duke vs Virginia Prediction
Virginia is the much better team in this matchup, and it will show from the opening minutes this week. Look for the Cavaliers to control this game on both sides of the ball against a subpar Duke team. Take Virginia this week to get the win and cover in North Carolina to secure an ACC championship title. Final Score Prediction, Virginia Cavaliers win and cover 27-17. Make sure when you place your Duke vs Virginia bet you are using the bet365 bonus code.
| # | Handicapper | Profit |
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| 3 |  Earle Sports Bets | +1,541.00 |
| 4 |  Dan Kaiser | +1,397.00 |
| 5 |  Mark Ruelle | +784.00 |
Best Picks:
- Virginia Cavaliers -2.5
- Under 58.5
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