East Tennessee State vs Tennessee Picks and Prediction for Saturday September 6 2025

By: Cameron Ross Published 09/02/2025, 11:23 PM ET

East Tennessee State Preview

These Tennessee State Buccaneers take a short road trip this week to Knoxville for a game against the Tennessee Volunteers. East Tennessee State is undefeated through one game this season following a 28-point victory against Murray State a week ago. Defensively, East Tennessee State controlled last week's matchup, giving up 17 points on 260 total yards, and the Buccaneers forced 2 turnovers. Offensively, East Tennessee State was dominant, scoring 45 points after 24 in the first half on 572 total yards. Stay in the loop with our College Football Picks.

Cade McNamara carried the load for the East Tennessee State offense a week ago, completing 12 passes for 146 yards and one score in the game. Devontae Houston led the team with 128 yards and two scores on 14 carries. D’Marius Rucker chipped in 65 yards and one score on 11 carries, while Khalil Eichelberger added 54 yards and two scores on 8 carries. Jeremiah Harrison led the team with three catches for 56 yards and one touchdown.

Tennessee Preview

The Tennessee Volunteers come into this week ranked #24 in the nation, undefeated on the year, after a 19-point home victory against Syracuse in the season opener. Defensively, Tennessee did enough, giving up just 26 points on 377 total yards and forcing 2 turnovers. The Tennessee offense was phenomenal, scoring 45 points on 493 yards after scoring 31 points in the first half.

Joey Aguilar led the way with the Tennessee offense last week, completing 16 passes for 247 yards and three scores. Start Thomas was the top ball carrier with 92 yards on 12 carries. DeSean Bishop added 11 carries for 82 yards and one score, and Peyton Lewis chipped in 38 yards and one touchdown on 8 carries. Braylon Staley led the team with 95 yards and one touchdown on 4 receptions.

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East Tennessee State vs Tennessee Pick

Both teams come into this game undefeated, but Tennessee is far and away the better team. Look for Tennessee to control the team on both sides of the ball as they overwhelm East Tennessee State for four quarters. Take the Volunteers to remain undefeated and defend their ranking this week with a blowout win and cover at home. Final Score Prediction, Tennessee Volunteers win and cover 48-7.

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