Grambling vs Ohio State Picks and Prediction for Saturday September 6 2025

By: Cameron Ross Updated 09/05/2025, 12:09 PM ET

Grambling Preview

The Grambling Tigers will be on the road for the first time this week with a game in Columbus against the Ohio State Buckeyes. Grambling is undefeated through one game coming into Week 2 following a 48-point blowout victory in Week 1 of the year. Defensively, Grambling dominated their game a week ago, giving up just seven points on 97 total yards and forcing 3 turnovers. Offensively, Grambling was a smoke show, scoring 55 points after 35 in the first half on 466 total yards of offense. Stay in the action with our College Football Picks.

C’zavian Teasett led the way for the Grambling offense a week ago, completing 20 passes for 203 yards and three scores in the game period. Ashton Frye completed 6 passes for 44 yards and one touchdown. Tre Bradford led the team with 56 yards and one touchdown on 6 carries. Tyson George was the top receiver on the roster with 63 yards and one touchdown on three receptions.

Ohio State Preview

The Ohio State Buckeyes are the #3-ranked team in the nation coming into this week undefeated following a 7-point victory over the then #1 Texas Longhorns. Ohio State was phenomenal on the defensive side a week ago, allowing just seven points on 336 total yards after forcing 1 turnover and giving up five third-down conversions. Offensively, Ohio State did just enough, scoring 14 points on 203 total yards after 7 points came in each half.

Julian Sayin carried the load for the Ohio State offense a week ago with 126 yards and one touchdown on 13 carries. CJ Donaldson was the top ball carrier in the game with 19 carries for 67 yards and one touchdown. Carnell Tate led the team with 49 yards and one touchdown on 2 catches.

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Grambling vs Ohio State Pick

Ohio State is going to dominate this week against a lackluster Grambling team at home. Look for the Buckeyes to dominate on both sides of the ball as their offense will explode. Take the Buckeyes to control this game start to finish, leading to a blowout win and cover in week 2. Final Score Prediction, Ohio State Buckeyes win and cover 63-0.

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