Houston vs Oklahoma State Picks and Prediction for Saturday, October 11, 2025

By: Cameron Ross Updated 10/10/2025, 10:54 PM ET
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Houston vs Oklahoma State Information

The Houston Cougars will visit Boone Pickens Stadium this week for a road game against the Oklahoma State Cowboys. Houston has four wins and one loss overall following a 24-point loss to Texas Tech at home last week. The Oklahoma State Cowboys enter this game struggling immensely, with just one win through five games played, following a four-game skid after a 28-point road loss to Arizona last week. Maximize your wagers by reading our free college football picks before kickoff.

Houston Preview

The Houston Cougars offense has been the team's biggest strength this season, as the Cougars average 27.2 points per game overall, but scored just 11 points and lost last week. Defensively, Houston has been top-tier, holding opponents to 17.6 points per game, but gave up 35 points against Texas Tech last week. Connor Weigman leads the Houston offense this season with 910 yards and six touchdowns on 70 completions. Dean Connors is the top running back on the team with 80 carries for 355 yards and three scores. Amari Thomas leads the team with 284 yards and two touchdowns on 16 receptions.

Oklahoma State Preview

The Oklahoma State Cowboys have been horrendous on both sides of the ball this season, with an average of just 16.4 points per game overall. Defensively, Oklahoma State has allowed an average of 36.2 points per game this season and has given up an average of 43.5 points per game during its current 4-game losing streak. Zane Flores has led the Oklahoma State offense this season through five games with 696 yards on 77 completions. Rodney Fields Jr. is the top ball carrier on the team with 213 yards on 41 carries. Shamar Rigby leads the team with 154 yards on 11 receptions this season.

New Mexico vs Boise State Prediction

Houston is having a great season and will come into this game with a bad taste in their mouth after the loss last week. Look for Houston to control this game against one of the worst teams in the country on Saturday. Take the Cougars to avenge their recent loss as they get the win and cover in blowout fashion this week in Stillwater. Final Score Prediction, Houston Cougars win and cover 49-13.

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Best Picks:

  • Houston Cougars -14.5
  • Over 48.5
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