Illinois vs Indiana Picks and Predictions for Saturday, September 20, 2025
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It's a Big Ten showdown this Saturday with Illinois vs Indiana at Memorial Stadium in Bloomington.
Illinois enters at 3-0 after a 38-0 win over Western Michigan, while Indiana is also 3-0 following a 73-0 victory against Indiana State. The game will air on NBC.
Get our Illinois vs Indiana prediction and score a touchdown with our college football picks all season long.
Illinois Preview
Quarterback Luke Altmyer has been poised and steady, completing 56 of 78 passes for 709 yards with 9 touchdowns and no interceptions. The Illini have used a balanced attack, as the run game has produced 494 yards and 9 scores. Kaden Feagin leads with 222 rushing yards and three touchdowns. In the passing attack, Hank Beatty has been the primary option with 289 yards on 19 catches, and Justin Bowick has contributed as a scoring threat with 3 touchdowns. The offensive line has allowed nine sacks, but Illinois has compensated with strength on the ground.
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Defensively, the Illini bring pressure with Gabe Jacas leading at 3.5 sacks, while Miles Scott tops the team in tackles with 14. This group has surrendered just 22 points in three games, and the challenge here will be handling Indiana’s explosive passing game.
Indiana Preview
Quarterback Fernando Mendoza has been outstanding, throwing for 708 yards and 9 touchdowns on 72% completions with no interceptions. He has a receiver group led by Omar Cooper Jr. with 299 yards and 4 scores and Elijah Sarratt with 164 yards and 3 touchdowns. Indiana has also been dominant on the ground, totaling 923 rushing yards at 6.9 per carry. Kaelon Black (217 yards) and Lee Beebe Jr. (209 yards) lead a backfield that has already found the end zone 8 times.
On defense, Louis Moore has been the anchor with 17 tackles and 2 interceptions, while Isaiah Jones provides pressure with 2 sacks. The Hoosiers have allowed just 23 points combined over their last two games, and they’ve forced 4 interceptions on the season. Indiana’s ability to stop the run and create turnovers makes it difficult to beat at home.
Illinois vs Indiana Prediction
Indiana will win a close game. Illinois’ offense and solid defense will keep this competitive, but Indiana’s offensive strength and home-field advantage will provide the difference. Expect the Hoosiers to find enough explosive plays to remain unbeaten. Final Score Prediction: Indiana Hoosiers win and cover ATS 35-23.
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Best Picks
- Indiana Hoosiers -4.5
- Total Over 54.5
