Indiana vs Penn State Picks & Prediction for Saturday, November 8, 2025

By: Thomas Pemberton Updated 11/08/2025, 01:44 AM ET
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The Penn State Nittany Lions will host the Indiana Hoosiers on Saturday. Kickoff is scheduled for noon est at Beaver Stadium. Indiana is a -13.5 road favorite and the over/under is set at 49.5 points. Penn State last played Indiana back in 2023 when they won 33-24. Looking to cash in this weekend? Start with our trusted college football picks.

Indiana Hoosiers Preview

The Indiana Hoosiers are playing dominating football this season. Indiana is 9-0 on the season with a 3-0 road record. The Hoosiers lead the nation averaging 46.4 points scored per game. Indiana beat Maryland 55-10 in their last game. QB Fernando Mendoza threw for 201 yards with a touchdown and interception in the win. Mendoza has 25 touchdowns and 4 interceptions on the season. Omar Cooper and Elijah Sarratt have been the top two receivers for Indiana. Cooper has 669 receiving yards. While Sarratt has 10 touchdowns. The Indiana Hoosiers have scored at least 55 points in two straight games.

Penn State Nittany Lions Preview

The Penn State Nittany Lions have had an underwhelming season to say the least. Penn State is 3-5 on the season. The Nittany Lions have lost five straight games and they carry a 3-2 home field record. Penn State lost to Ohio State 38-14 in their last game. Penn State was shutout 21-0 in the second half of the loss. The Nittany Lions are averaging 31.5 points scored on the season. QB Drew Allar has 8 touchdowns and 3 interceptions on the season.

Indiana vs Penn State Picks & Prediction

The Indiana Hoosiers are 6-3 against the spread on the season. Penn State has covered the spread in just one game all year. The Hoosiers will be the better team on the both sides of the ball in this matchup. Penn State hasn't played a complete good game since Week 3. Watch for Indiana to continue to make their push to the playoffs.

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  • Final Score Prediction: Indiana Hoosiers win 42-20 and cover ATS.

Indiana vs Penn State Best Free Pick

  • Indiana Hoosiers -13.5
  • OVER 49.5

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