Indiana vs Purdue Picks & Prediction for Friday, November 28, 2025
The Purdue Boilermakers will host the Indiana Hoosiers on Friday evening. Kickoff is scheduled for 7:30 PM est on NBC. Indiana is a -28.5 road favorite and over/under is 53.5 points. Indiana shutout Purdue 66-0 in their last meeting last season. Stay up to date with our expert's Free College Football Picks.
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Indiana Hoosiers Preview
The Indiana Hoosiers are the #2 team in the country with a 11-0 record. Indiana heads into Purdue with a 4-0 road record. The Hoosiers beat Wisconsin 31-7 in their last game. QB Frenando Mendoza threw for 299 yards with 4 touchdowns. Mendoza has 30 touchdowns and 5 interceptions on the season. Indiana is 2nd best in the country averaging 43.3 points scored per game. Wide receivers Omar Cooper and Elijah Sarratt lead Indiana on the season with 10 touchdowns each. The Hoosiers have four different players with 5 rushing touchdowns each. The best sportsbooks are the best way to go when you are betting on Indiana.
Purdue Boilermakers Preview
The Purdue Boilermakers have struggled this season. Purdue is 2-9 on the year with a 2-4 home field record. The Boilermakers head into this week riding a nine game losing streak. Purdue lost to Washington 49-13 in their last game played. QB Malachi Singleton threw for 150 yards with a touchdown in the loss. Singleton has 5 passing touchdowns, 1 rushing touchdown, and 2 interceptions on the season. Purdue is averaging 348 yards per game with 20.2 points scored. The Boilermakers haven't scored more than 16 points in three straight games. Make sure you know about how the fans are looking on prediction markets for Purdue with the Onyx Odds promo code.
Indiana vs Purdue Picks & Prediction
The Indiana Hoosiers have played very good football all season long. The Hoosiers are 6-5 against the spread. While Purdue is 4-6-1 against the spread. Indiana has scored more than 50 points in two of their last four games. Watch for the Hoosier to dominate a bad Purdue team this week. Getting the most out of your bets on Indiana vs Purdue can be done by using the Fanatics Sportsbook promo code.
- Final Score Prediction: Indiana Hoosiers win 45-16 and cover ATS
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +2,063.00 |
| 2 |  Chip Chirimbes | +1,495.00 |
| 3 |  Ross Benjamin | +1,490.00 |
| 4 |  Earle Sports Bets | +1,379.00 |
| 5 |  Dan Kaiser | +1,323.00 |
Indiana vs Purdue Best Free Picks
- Indiana Hoosiers -28.5
- OVER 53.5
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