Iowa vs Iowa State Picks and Predictions for Saturday September 6 2025

By: David Anicetti Published 09/01/2025, 11:19 PM ET

Iowa Preview

The Iowa Hawkeyes visit Jack Trice Stadium in Ames, Iowa Saturday to play the No. 22-ranked Iowa State Cyclones. Iowa opened its regular season with a 34-7 victory over UAlbany on Saturday. Iowa's defense was the key to the victory, holding the Great Danes to 177 yards of total offense. Iowa generated 358 yards of total offense, converting 10 of 16 third-down attempts. Make sure you are fully prepared for the college action with our college football picks.

Iowa quarterback Mark Gronkowski has thrown for 44 yards with one touchdown. Xavier Williams leads Iowa in rushing, with 122 yards and one touchdown, and Jacob Gill leads all receivers with 13 yards. Defensive back Zach Lutmer made a team-high five tackles on opening night. Iowa made two quarterback sacks, but the Hawkeyes did not intercept the pass.

Iowa State Preview

The Iowa State Cyclones improved to 2-0 following a 55-7 rout of South Dakota on Saturday. Iowa State opened its regular season with a 24-21 victory over Kansas State. In the victory over South Dakota, Iowa State gained 529 yards of total offense, while holding South Dakota to just 208 yards of total offense and forcing the Coyotes into a pair of turnovers.

Iowa State quarterback Rocco Becht has thrown for 461 yards with five touchdowns. Carson Hansen is the leading rusher with 90 yards, while Brett Eskildsen is the leading receiver with 123 yards and one touchdown reception. Defensive back Marcus Neal Jr is the leading tackler with 13. Iowa State has made just one quarterback sack and has intercepted two passes.

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Iowa vs Iowa State Prediction

Iowa State is off to a strong start with two straight wins, scoring an average of 39.5 points per game, while allowing an average of just 14 points per game. Iowa State's offense has been very strong on the ground, averaging 176.5 yards per game. Although Saturday’s opponent, Iowa, will not be a pushover, the Cyclones will perform well enough against a weaker Iowa side that does not have the same talent as in years past. Final Score Prediction: Iowa State Cyclones win and cover ATS 30-13.

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