Jackson State vs Southern Miss Picks and Prediction September 6, 2025

By: Jake Allman Published 09/01/2025, 09:20 PM ET

Jackson State is 1-0 after a 28-14 win over Hampton in Week 1, extending a five-game win streak dating back to last season. Southern Miss dropped its opener 34-17 to Mississippi State and has now lost six straight games overall. These programs meet on Saturday, September 6, at 3:00 PM ET in Hattiesburg. Dominate the college scene with our College Football picks.

Jackson State Preview

Jackson State handled Hampton behind a strong start from quarterback Jacobian Morgan, who threw for 143 yards on 15-of-30 passing. Running back Ahmad Miller took over with 172 yards and 2 touchdowns on just 10 carries, powering the Tigers to a balanced offensive attack. The win was a continuation of a dominant stretch from late last season, where Jackson State outscored opponents by a combined 161-44 over the final four games.

Defensively, the Tigers allowed just 14 points and limited Hampton’s ground game throughout. Quincy Ivory led the defense with 2 sacks and 8 total tackles, while the secondary held firm. Jackson State’s defense has now given up fewer than 15 points in four of its last five games. That group will be tested more by a mobile quarterback in Week 2, but the front line has been consistently disruptive.

Southern Miss Preview

Southern Miss showed some life offensively in the loss to Mississippi State, with quarterback Braylon Braxton throwing for 199 yards and 2 touchdowns while also leading the team with 58 rushing yards. However, the Golden Eagles couldn’t keep up after falling behind early and struggled to sustain drives. Receiver Carl Chester had a solid outing with 5 catches for 52 yards, but the rushing game beyond Braxton was a non-factor.

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

The defense gave up 34 points and was unable to contain the Bulldogs' passing game. Josh Moten recorded 12 tackles, but the unit allowed 400+ total yards for the fifth straight game. With Southern Miss now surrendering an average of 43.2 points across its last five outings, pressure is on this group to show signs of improvement quickly.

Jackson State vs Southern Miss Pick

The Tigers are in better form on both sides of the ball and come in with a clear edge in defensive consistency. Southern Miss has now allowed 34+ points in six straight games and faces a Jackson State offense that just posted 28 behind a dominant ground game. Final Score Prediction: Jackson State 27, Southern Miss 21

Betting on College Football?

Bet with other College Football fans at the best sportsbooks
Sign up today and get started with the latest college football sportsbook promos

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.

Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelplineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-HOPENY or text HOPENY (467369) (NY). 21+ (18+ DC, IA, KY, WV) only. New users only or text HOPENY (467369) (NY). Casino, First online real money wager only. $5 first deposit required. Min $5 wager required for 5 consecutive days. Bonus issued as non-withdrawable Bet Reset tokens. Refund from token issued as nonwithdrawable bonus bet that expire 7 days after receipt. Max refund $200 per day. Restrictions apply, including token expiration. See full terms at fanduel.com/sportsbook. Call 1-877-770-7867 (LA).

Min. Deposit $5

Cashable No

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $150 issued as non-withdrawable Bonus Bets that expire in 7 days after issuance. Stake removed from payout. Reward issued as $50 in Bonus Bets every 7 days via click-to-claim for 14 days. 7 days = 168hrs. Terms: sportsbook.draftkings.com/promos. Ends 8/23/26 at 11:59 PM ET. Sponsored by DK.