Kansas vs. Iowa State Picks and Prediction for Saturday, November 22, 2025

By: Dylan Hellebrand Updated 11/22/2025, 01:27 AM ET
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On Saturday, the Kansas Jayhawks (5-5) face off against the Iowa State Cyclones (6-4) at Jack Trice Stadium in Ames, Iowa. This game will be aired on FS1. Get the edge this weekend with our free college football picks backed by data and trends.

Kansas vs Iowa State Game Information

  • November 22, 2025
  • 12:00pm EST
  • Jack Trice Stadium
  • FS1
  • 44° cloudy/sunny at start time

Iowa State Form & Recent Results

Iowa State heads into this game with a bit of confidence after snapping a rough patch with a win, though they’ve still lost four of their last five. Their most recent game was a tight 20-17 victory over TCU, where quarterback Rocco Becht completed 9 of his 24 passes, tossing one touchdown but also throwing two picks. Over the course of this season, Becht has put up 2,230 passing yards. Running back Carson Hansen has racked up 721 yards, providing some stability to the offense. In the receiving corps, Brett Eskildsen leads with 434 yards, and Benjamin Brahmer isn’t far behind with 388 yards. The Cyclone defense, however, has struggled lately, giving up an average of 28.8 points over their last five games. Iowa State is now hoping that their latest win can spark a turnaround as they aim to even up their conference record against Kansas in this upcoming game. Make sure you know about how the fans are looking on prediction markets for Iowa State with the Thrillz promo code.

Kansas Form & Recent Results

Kansas heads into this matchup hoping to bounce back after a tough loss in their last game, which added to a stretch where they’ve dropped three of their last five contests. In their most recent outing, they fell to Arizona by a score of 24-20. Quarterback Jalon Daniels completed 15 of 29 passes, finishing with a touchdown for the Jayhawks. Throughout the season, Daniels has thrown for 2,190 yards, showing his ability to move the ball through the air. Daniel Hishaw Jr. leads the team with 430 rushing yards, closely followed by fellow running back Leshon Williams, who has gained 414 yards so far this year. Wide receiver Emmanuel Henderson Jr. has been a reliable target for Daniels, hauling in 638 receiving yards over the course of the season. Defensively, Kansas will need to tighten things up, as they’ve allowed an average of 29.8 points per game over their last five. With bowl season on the horizon, the Jayhawks are eyeing this game as a chance to capture their sixth win and lock in an official bowl game berth. Make the most of your bets on Kansas by using the sportsbook promos.

Key Players for Kansas and Iowa State

  • KU QB Jalon Daniels this season: 175/269, 21 TD, 3 INT
  • ISU QB Rocco Becht this season: 178/297, 12 TD, 9 INT

Betting Odds & Market Overview:

  • ISU -3.5; O/U 55.5

Iowa State vs Kansas Picks and Prediction 

The Jayhawks are just one win away from securing a spot in a bowl game this season, making their next matchup crucial. Meanwhile, the Cyclones are hoping to pick up back-to-back victories as they try to build momentum. With both teams currently sharing the same record in the conference, every play will matter as they battle for a leg up in the standings. Final Score Predictions, Iowa State Cyclones win but fail to cover the spread, 27-25. Make sure when you place your Iowa State vs Kansas bet you are using the bet365 bonus code.

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