Louisville vs Ole Miss Picks and Predictions for Sunday, September 6th, 2026

By: Cameron Ross Published 09/05/2026, 10:51 AM ET

Louisville vs Ole Miss Game Information

The Louisville Cardinals began the 2026 season Sunday night with a 7:30 PM matchup inside Nissan Stadium in Nashville, TN, for the Liberty Mutual Music City kickoff against the Ole Miss Rebels. Louisville is the #24-ranked team in the nation coming into 2026 after winning 9 games last year, following a 5-point victory in the Bush’s Boca Raton Bowl against Toledo 2 days before Christmas. The Ole Miss Rebels open the 2026 season Sunday ranked #9 in the country after a 13-win campaign a year ago that ended in a 4-point loss to the Miami Hurricanes in the College Football Playoff semifinals. Stay in the news with our College Football Picks.

Louisville Preview

Lincoln Keinholz will take over the Louisville offense this season after transferring in last year. In 2 years at Ohio State, Keinholz completed 21 passes for 250 yards and 1 score. Isaac Brown will again be the leader out of the Louisville backfield this season after leading the team with 884 yards and 7 touchdowns on 101 carries last year. Keyjuan Brown also returns after 704 yards and 6 touchdowns on 96 carries. Jaleel Skinner is the top receiver back this season after 204 yards and 2 touchdowns on 21 catches a year ago.

Ole Miss Preview

Trindad Chambliss is back this season for Ole Miss after leading the team with 3937 yards and 22 scores on 294 completions, along with 527 yards and 8 touchdowns on 133 carries. Kewan Lacy returns this season after 1567 yards and 24 scores on 306 carries in 2025. Deuce Alexander is the top receiver back this season after 684 yards and 2 scores on 44 catches last year.

Louisville vs Ole Miss Pick

This is a matchup between 2 of the top teams in the country on Sunday, as each will look to make their mark on 2026. Ole Miss, however, is the better overall team coming off a tremendous year last season. Look for Ole Miss to use their depth and talent all over the field to overwhelm a good Louisville team start to finish Sunday night, resulting in the win and cover in Nashville to open the year.

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  • Pick: Ole Miss Rebels -6.5
  • Lean:  Over 54.5

Final Score Prediction: Ole Miss Rebels win and cover 41-31.

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