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LSU vs Louisiana Tech Picks and Predictions for Saturday September 6 2025

By: Jeremy O'Quinn Published 09/01/2025, 08:13 PM ET

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The LSU Tigers are heading to Tiger Stadium in week two of college football, where they will face the Louisiana Tech Bulldogs. Get the rest of our free NCAAF picks here! The LSU Tigers sit 1-0, ranked 9th in the nation. LSU comes into week 2 riding a 17-10 upset victory over No. 4 Clemson in their season opener. Tigers’ quarterback Garrett Nussmeier was stellar, completing 28 of 38 passes for 230 yards and a touchdown and earning SEC Co-Offensive Player of the Week honors. On the ground, Caden Durham led the rush with 17 carries for 74 yards and a touchdown, while receiver Aaron Anderson was LSU’s top target, hauling in 6 catches for 99 yards   .

Louisiana Tech Bulldogs Preview

The Louisiana Tech Bulldogs currently sit 1-0 in Conference USA. The Bulldogs opened their season at home with a 24-0 shutout win over Southeastern Louisiana. Louisiana Tech quarterback Trey Kukuk was efficient, completing 14 of 19 passes for 130 yards and a touchdown. Running back Clay Thevenin headlined the rushing effort with 61 yards on 6 carries and a touchdown, and it was tight end Eli Finley who led the all receivers with 4 catches for 59 yards.

LSU vs Louisiana Tech Pick

The LSU Tigers once again look like a juggernaut in the SEC after pulling off an upset win over Clemson, while Louisiana Tech comes off a win, but has their work cut out for them in week 2. LSU undoubtedly controls this game start to finish, expect them to cover the -37.5 spread. Final score prediction, LSU wins 50-9.

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