LSU vs Ole Miss Picks and Prediction for Saturday, September 19, 2026
The 7th-ranked LSU Tigers visit the 8th-ranked Ole Miss Rebels on Saturday at Vaught-Hemingway Stadium in Oxford, with the opening kickoff scheduled for 7:30 PM ET on ABC. LSU is 2-0 overall and 0-0 in the SEC after beating the Louisiana Tech Bulldogs 45-14, following a 51-10 victory over the Clemson Tigers. Ole Miss is 2-0 overall and 0-0 in the SEC after beating the Charlotte 49ers 41-9, one week after a 41-38 victory over the Louisville Cardinals. Find your winner using our free NCAAF picks.
LSU Tigers
LSU has scored 96 points through two games while averaging 358 passing yards and 228 rushing yards per game. Sam Leavitt has completed 41 of 66 passes for 574 yards and two touchdowns, but his four interceptions are an issue entering SEC play. Dilin Jones leads the rushing attack with 179 yards and two touchdowns, while Leavitt has added 135 yards and five scores. Trey'Dez Green leads the receivers with 162 yards, followed by Winston Watkins Jr. with 153.
The Tigers have allowed only 12 points per game after holding Clemson to 10 and Louisiana Tech to 14. LSU has been especially active around opposing quarterbacks, recording 12 sacks through two games. Princewill Umanmielen leads the defense with five sacks, while Deuce Geralds has two and Jordan Ross has 1.5. TJ Dottery has a team-high 14 tackles. Ross and DJ Pickett have interceptions, with Ross returning his 30 yards for a touchdown.
Injuries: No injuries to report.
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Ole Miss Rebels
Ole Miss has scored 82 points through two games while averaging 314.5 passing yards and 139.5 rushing yards per contest. Trinidad Chambliss has completed 44 of 62 passes for 561 yards, five touchdowns and one interception. Kewan Lacy leads the ground game with 148 yards and three touchdowns on 30 carries. Deuce Alexander has been the Rebels’ top receiving threat, catching 13 passes for 235 yards and two touchdowns. Horatio Fields has added 113 yards and a score.
The Rebels have allowed 23.5 points per game, with 38 coming against Louisville before holding Charlotte to nine. Ole Miss has recorded four sacks and one interception. Tah'j Butler and Keaton Thomas lead the defense with 12 tackles apiece, while Luke Ferrelli has 11 tackles and a sack. Kam Franklin and Jordan Renaud have also recorded sacks. Nick Cull has the Rebels’ interception, returning it 38 yards.
Injuries: No injuries to report.
LSU vs Ole Miss Prediction
Ole Miss has a productive passing attack and home-field advantage, but LSU’s defensive front creates the biggest matchup problem. The Tigers have 12 sacks through two games, while Ole Miss has allowed only one, setting up an important battle around Chambliss. LSU also enters allowing just 12 points per game. Leavitt’s four interceptions give Ole Miss opportunities to stay close, and Chambliss has taken better care of the ball. Still, LSU has produced 586 total yards per game and can attack with both Jones and Leavitt on the ground. The Tigers will create enough pressure and finish more drives to earn the road victory. Final Score Prediction: LSU Tigers win, 31-27.
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- LSU Tigers -3 (-110)
- Under 58.5 (-102)
