LSU vs Ole Miss Picks and Prediction for Saturday September 27 2025

By: Eddie Kline Updated 09/27/2025, 01:23 AM ET

LSU Preview

A Top 25 college football showdown will take place on Saturday afternoon, when the LSU Tigers invade Vaught-Hemingway Stadium to take on the Ole Miss Rebels. Saturday success begins with free college football picks you can rely on. The third-ranked Tigers (4-0) have national championship aspirations and are allowing just 9.3 points per game. On Saturday, LSU erupted for 28 points during the second quarter of a 56-10 home victory versus FCS SE Louisiana.

Heisman Trophy contender Garrett Nussmeier completed 25 of 31 passes for 273 yards and three touchdowns. LSU sophomore QB Ju’Juan Johnson rushed for two touchdowns and Nussmeier added a score on the ground. Senior TE Bauer Sharp caught five passes for 73 yards and a touchdown.

Ole Miss Preview

The Ole Miss Rebels were the most talented team to miss last season’s College Football Playoff and could challenge for one of the 12 spots this year. The 13th ranked Rebels (4-0) rank fourth in the SEC Conference in total offense and are averaging 44.8 points per contest. Last week, Ole Miss limited Tulane to 109 passing yards during a convincing 45-10 home victory.

Dual-threat Ole Miss QB Trinidad Chambliss passed for 307 yards and added a game-high 112 rushing yards. Chambliss threw touchdown passes to Dae’quan Wright and Deuce Alexander. Sophomore RB Kewan Lacy contributed two rushing scores for the Rebels.

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LSU vs Ole Miss pick

These two teams were extremely well matched last season and LSU needed overtime to escape with a three-point home victory. The Tigers have the better quarterback and the better defense. Take LSU to win on the road. Final Score Prediction, LSU Tigers win 31-24.

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