Mississippi State vs South Carolina Picks and Predictions for Saturday, September 19th, 2026

By: Cameron Ross Published 09/18/2026, 11:45 PM ET

Mississippi State vs South Carolina Game Information

The Mississippi State Bulldogs will travel to Columbia on Saturday for a 4:15 PM matchup inside Williams-Brice Stadium against the South Carolina Gamecocks. Both teams are undefeated after convincing wins in their first 2 games. Mississippi State defeated Minnesota by 25 points, while South Carolina cruised past Towson by 36. ย Stay in the news with our College Football Picks.

Mississippi State Preview

Kamario Taylor leads the Mississippi State offense this season with 581 yards and 7 touchdowns on 38 completions. Taylor has also contributed 145 yards and 1 score on 19 carries. Fluff Bothwell leads the Bulldogs with 165 yards and 2 touchdowns on 27 carries. J.J. Hill has added 118 yards and 2 scores on only 7 carries, while Kolin Wilson has produced 87 yards on 15 attempts. Anthony Evans III leads Mississippi State through the air with 239 yards and 2 touchdowns on 14 catches. Marquis Johnson has added 107 yards and 1 score on 4 grabs, while Zion Ragins has recorded 98 yards and 2 touchdowns on 6 receptions. Sanfrisco Magee has chipped in 77 yards and 2 scores on 8 catches.

South Carolina Preview

LaNorris Sellers is leading South Carolina with 366 yards and 3 touchdowns on 29 completions, along with 120 yards and 1 score on 9 carries. Matt Fuller leads the Gamecocks on the ground with 199 yards and 2 touchdowns on 21 attempts. Jabree Coleman has added 109 yards and 3 scores on 10 carries, while Isaiah Augustave has produced 104 yards and 2 touchdowns on 11 attempts. Nyck Harbor leads the team with 105 yards on 7 catches. Donovan Murph has contributed 92 yards and 2 scores on 4 receptions, while DJ Black has added 62 yards on 3 grabs.

Mississippi State vs South Carolina Pick

Both teams have been impressive, making this one of Saturdayโ€™s more intriguing matchups. Mississippi State has scored 100 points through 2 games, but South Carolina has allowed only 9. Sellersโ€™ dual-threat ability will test the Bulldogs differently than their first 2 opponents, and the Gamecocks have multiple running backs capable of controlling the game. Mississippi State should create several explosive plays and keep the score close into the fourth quarter. However, South Carolinaโ€™s defense and home-field advantage should make the difference during the closing possessions. Take the Gamecocks to secure the victory, but Mississippi State should stay within the number.

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  • Pick: Mississippi State +4
  • Secondary: Over 58.5

Final Score Prediction: South Carolina 34, Mississippi State 31

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